MyBioSource.com's APOBEC3A/B Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The APOBEC3A/B Antibody was generated using APOBEC3A and APOBEC3B deletion hybrid, and APOBEC3A_B as the antigen and it reacts with Human.
Description
Function: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Subunit Structure: Interacts with AGO2. Interacts with TRIB3 (via N-terminus).
Similarity: Belongs to the cytidine and deoxycytidylate deaminase family